Association between calprotectin and volatile fatty acids in patients with inflammatory bowel diseases

Aim. To evaluate the content of calprotectin and volatile fatty acids (VFAs) in feces patients with inflammatory bowel disease (IBD). Materials methods. 61 (33 men 28 women) IBD aged 20 to 66 years (the mean indicator was 41.80 ± 1.14 years) were examined. The treated Department Intestinal Diseases SI “Institute Gastroenterology National Academy Medical Sciences Ukraine”. All divided into two groups: Group I – 46 ulcerative colitis (UC) II 15 Crohn’s (CD). control group consisted 10 practically healthy people (donors). Calprotectin detection fecal samples carried out using a kit “Immundiagnostik”, Germany. Fecal VFAs analyzed hardware-software complex for medical research gas chromatograph Chromatek-Crystal 5000. Results. A significant increase found. Its amount depended on nosology more expressed UC (3.5 times higher (P < 0.05) than that CD). observed changes accompanied by an propionic (C3) acid decrease acetic (C2), butyric (C4) coprofiltrates examined patients. detected imbalance led acids, which pronounced CD. An association between levels VFA identified. Thus, correlation analysis allowed establish relationship (r = 0.370; P 0.046). Conclusions. In case active inflammation, there is (acetic acids) accordance degree activity, allows use these indicators assess efficacy therapies.